The features of seizures have been precisely classified both in humans ( Fisher, Cross et al. Epileptic seizures occur at variable frequencies, implying long term recordings (over days or weeks) for an accurate quantification, which is essential for the characterization of models and the assessment of the effects of treatments on spontaneous seizures. The use of rodent models of epilepsy enables to shed light on these two mechanisms and to test new anti-epileptic treatments the evaluation of these treatments on spontaneous seizures of models showing chronic epilepsy can greatly improve the translational value of the study ( Loscher and Schmidt 2011). Many research laboratories study the mechanisms leading to the pathological state (chronic epilepsy), called epileptogenesis, and the mechanisms triggering seizures, called ictogenesis ( Pitkänen 2017). Although many anti-epileptic drugs have been commercialized in the last decades, about one-third of people with epilepsy are still pharmacoresistant ( Loscher and Schmidt 2011). It is an episodic disorder characterized by the unpredictable appearance of abnormal cerebral activity leading to recurrent seizures and by a wide range of co-morbidities ( Scheffer, Berkovic et al. Epilepsy is a very invalidating pathology and the fourth most common neurological disease ( Fisher, Acevedo et al.

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